Milano noted that she spends some of her time in Truckee, California, which is currently represented by Republican Rep. Tom McClintock, whom the actress has criticized for opposing an anti-Asian hate crimes bill.
"I’m looking at California’s 4th District to potentially run against McClintock," she told ITK, according to The Hill.
Milano claimed the GOP has "had a strong arm there in the 4th [Congressional] District," adding she "would love to maybe consider flipping that seat blue."
"It's going to take someone with, I think, name recognition and deep pockets to be able to run against McClintock, and so I'm considering it," she stated. "I'm basically gathering information right now, speaking to different consultants, speaking to the community."
Milano, who has become a champion for liberal causes in recent years, previously teased a run against McClintock after he voted against S. 937, known as the "COVID-19 Hate Crimes Act."
"Congressman McClintock was one of the 63 republicans to oppose Asian Hate Crimes bill," she tweeted on May 20. "This is my Congressman. Should I run against him?"
A representative for McClintock's reelection campaign declared he'd welcome Milano into the race.
"We welcome a little celebrity, such as it is, to accentuate the issues facing our country. Her record of taking extreme leftist positions over the years will create a target rich environment," Chris Baker, a campaign spokesman for McClintock, wrote in an emailed statement to the Washington Examiner.
Milano has made headlines for some of her controversial stances. Last September, she suggested the Republican Party "should be tried for treason" and referred to then-Democratic nominee Joe Biden as America’s "only hope."
"The entire @GOP should be tried for treason,” the Melrose Place actress tweeted on Sept. 9 with the hashtag #TrumpKnewVoteBlue.
Milano’s tweet was reportedly in reference to an excerpt from a book written by veteran journalist Bob Woodward that included a comment from then-President Donald Trump saying he "wanted to always play [the coronavirus] down." Trump defended his statement by arguing he took the virus seriously but didn’t want to incite panic.
California's 4th Congressional District has a partisan voter index of R+10, meaning the district is Republican-leaning, according to the Cook Political Report.
Milano is not the only television personality considering a run for office in the Golden State. Republican Caitlyn Jenner, a former Olympian known for Keeping up with the Kardashians, announced in April she would challenge Gov. Gavin Newsom in the state's likely recall election, saying California has been "reduced by one-party rule that places politics over progress and special interests over people."
A representative for McClintock did not immediately respond to request for comment.