WATCH: Here's The One Reason Biden's Co-Chair Says Trump Could Beat Him Again...

Landrieu attributed this shift to the changing dynamics within the electorate.

Blitzer, the CNN host, cited a recent New York Times/Siena poll during the discussion, highlighting Biden's dwindling support among key voter groups such as women, young adults, and Black voters. Landrieu, however, questioned the accuracy of the poll before shifting the conversation to the perceived war Trump has waged on women's reproductive health.

"Assuming that some of those things are occurring, it's not really a big surprise," Landrieu said. "There are tectonic shifts going on amongst the electorates. Women in this country understand that Trump has declared war on them by appointing three Supreme Court justices that have reversed Roe versus Wade."

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Landrieu continued, pointing to the recent outlawing of in vitro fertilization in Alabama and the criminalization of miscarriages in Ohio as evidence of this war. He suggested that women are increasingly questioning the government's involvement in their reproductive health.

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Landrieu also emphasized the Biden campaign's commitment to fighting for every vote, referencing Biden's victory in the 2020 election. "We're going to go back to every constituency, we're going to earn every vote," he stated. He further outlined the president's strategy of discussing his record, the challenges he faced upon taking office, and his future plans.

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"The bigger point that Joe Biden wants to tell America is that America is worth fighting for, that democracy [is at] risk, and that when we do things together we can do big things," Landrieu added.

He contrasted this with Trump's approach, which he characterized as dismissive of differing viewpoints and focused on creating chaos. "Donald Trump [is] sending the message, especially to Nikki Haley's supporter, [that] says, 'Hey babe, it's my way or the highway. And I'm interested in governing and chaos' because tearing things down is what he thinks works," Landrieu said. He concluded by expressing confidence in Biden's ability to defeat Trump again.

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The New York Times/Siena poll, conducted from February 25 to 28, revealed that only one in four of the 980 registered voters surveyed believes the country is moving in the right direction. The poll also indicated that more than twice the number of voters feel Biden's policies have hurt them compared to those who believe they have benefited. Furthermore, the data suggested that Trump is making inroads into traditionally Democratic voter groups, with women now evenly split, Latino voters leaning towards Trump, and Black voter support for Biden significantly diminishing.