She explained that the U.S. alone cannot fight the factors that force people to leave Guatemala, Honduras and El Salvador - like corruption and violence - yet, she claimed the United Nations, Japan, and Mexico had all agreed to help with the push.
The plans involve working with the private sector to attempt to accelerate change in Central America.
Officials explained it amounted to a 'hard-nosed' approach.
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Though, even Harris acknowledged its limitations.
'We will build on what works, and we will pivot away from what does not work,' she wrote in a two-page letter to launch the strategy
.'It will not be easy, and progress will not be instantaneous, but we are committed to getting it right.'
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The administration has met pressure for months as the number of people appearing at the southern border breaks historic records.
Harris was tapped in March to take on one of the president's most daunting jobs when she was put in command of tackling the factors behind rising illegal immigration.
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Even July's scorching temperatures have not reduced the amounts.
On Monday night, a group of 509 migrants turned themselves in near the border in Hidalgo, Texas. Hours earlier, a different group of 336 migrants was found nearby, according to Brian Hastings, the Border Patrol chief for the Rio Grande Valley, a hot spot for arrivals.
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At the same time, it emerged that tens of thousands of immigrants who were arrested and then freed without a court date had disappeared, according to Department of Homeland data obtained by Axios.
Of 50,000 who came between mid-March and mid-July, just 13 percent reported to Immigration and Customs Enforcement offices as instructed.
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Senior administration officials said Biden and Harris took over a 'dysfunctional system.
'For this strategy to be successful, we will have to undertake sustained efforts, which is both hard work over time, but also a very hard-nosed approach to having an impact on the ground for the people of the region who are suffering so badly,' said one throughout a call with reporters.
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The administration’s strategy is split into five parts, laid out in a White House fact sheet.
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Part one involves tackling economic insecurity and insecurity in the region. Part two aims at corruption by advancing the rule of law.
Pillar three covers human rights, labor rights and a free press, while pillar four tries to fight violence, extortion and other forms of organized crime, such as trafficking networks.
The fifth pillar deals with 'combating sexual, gender-based, and domestic violence,' according to the fact sheet.
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