In his opening monologue, Maher examined the Supreme Court leak that showed five justices are prepared to revise the landmark abortion case.
But the talk show host couldn't resist taking a jab at transgender people and their supporters' obsession with policing pronouns.
"Louisiana wants to pass a law that says flat out if you get an abortion, you get charged with murder. Wow," Maher said, referencing the state's controversial abortion bill.
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"Suddenly getting the right pronoun doesn’t seem so big, does it?"
Along with the Louisiana bill, Maher slammed the wave of states looking to set more restrictive abortion laws as they expected Roe V. Wade to be overturned.
"Oklahoma already has one on the books. Six weeks, can’t get an [abortion] after six weeks," he said. "Most women don’t even know they’re pregnant at six weeks.
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"They don’t even know if they like the guy. Six weeks. That’s a quick look.
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Despite what he said, Maher condemned pro-choice protestors later in the show, saying their claim that ending Roe V. Wade would send U.S. abortion rights back 50 years is "factually inaccurate."
Maher said the ruling is not "settled law" and that it would not have the drastic impact pro-choice defenders believe it would.
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"Most abortions now, even when you go to a clinic, are done with the pill," Maher said. The pill. And pills are easy to get in America."
"So, you know, we're not for the people who say we're going back to 1973. That's just factually inaccurate."
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He added said that abortion rights in most European countries are far more limiting than in the U.S.
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"The modern countries of Europe are way more restrictive than we are or what they're even proposing," Maher said. "If you are pro-choice, you would like it a lot less in Germany, Italy, France, Spain, and Switzerland."
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Germany, France and Spain all set abortion limits at 14 weeks into the pregancy, with Italy and Switzerland setting the cap at 12 weeks.
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Even the more liberal Norway and Denmark set the limit at 12 weeks, with Sweden limiting abortions at 18 weeks.
According to the Guttmacher Institute, only 22 states set abortion limits at 20 weeks or less, and most states that have set a shorter time frame cannot enforce the law as they have faced numerous legal challenges.
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Maher also asserted that whatever the Supreme Court decides on would always be fluid as the law could be changed again in the future.
"This whole bulls*** argument about, 'Well, it's settled law.' So was segregation," Maher said. "Plessy vs. Ferguson was 'settled law' in 1896 and thank God somebody said let's unsettle it."