In 1999, alcoholic cirrhosis -- an evolved form of alcohol-related liver disease -- killed just more than 6,000 Americans (a rate of 3 per 100,000). By 2019, deaths from the condition had skyrocketed to almost 24,000 (a rate of 11 per 100,000).
"The hypothesis is that people are drinking more and starting earlier in life," announced lead researcher Dr. Charles Hennekens, the First Sir Richard Doll Professor & Senior Academic Adviser to the Dean at the Charles E. Schmidt College of Medicine at Florida Atlantic University in Boca Raton. Though there may be additional factors at work, Hennekens continued, including a dramatic increase in obesity, along with more sedentary lifestyles.
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"That leads to fatty liver," Hennekens announced. "The same kind of thing that alcohol does. My hypothesis is that the reason we're seeing more of liver disease earlier is not just that people are drinking more, but that they're eating more and exercising less, so the damage to the liver is accelerating."
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Obesity and lack of exercise are also at the root of the epidemic of diabetes, as well as heart disease, stroke, and some cancers. "The risk factors are the same," he stressed.
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Hennekens announced that as far as drinking goes, people should restrict the amount of alcohol they drink to no more than two drinks a day for men and no more than one for women.
Doctors should counsel their patients that those who consume lots of alcohol have the highest death rates from both cirrhosis and heart disease, he went on.
Alcoholic cirrhosis accounts for one-third of all liver transplants in the United States, the study authors stressed.
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"While the data indicate that those who have one to two drinks daily have lower risks of cardiovascular disease than nondrinkers, it is also true that the difference between drinking smaller and larger amounts of alcohol means the difference between preventing and causing premature death," Hennekens announced.
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For the study, Hennekens and his colleagues utilized data from the U.S. Centers for Disease Control and Prevention to look at trends in death from alcoholic cirrhosis from 1999 to 2019.
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The investigators discovered that throughout those two decades there were statistically substantial increases in deaths from alcoholic cirrhosis in every age group from 25 and up. The largest increase was sevenfold among those aged 24 to 35 and the steepest growth was seen among those aged 65 to 74.
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The report was published online recently in the American Journal of Medicine.
Dr. Tiffany Wu, a gastroenterologist at the Mayo Clinic in Rochester, Minn., announced that alcohol-associated liver disease is one of the leading causes of liver-related deaths in the United States.
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"The rising prevalence of high-risk drinking and alcohol use disorder has fueled these trends in the development of chronic liver disease and its complications," she stated. "Although effective treatments are available for alcohol use disorder, they are currently underutilized."
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Barriers to care include other medical conditions, the stigma around addiction, and limited access to care, Wu stated.
"Existing care delivery models have been further restricted due to challenges related to the pandemic," she stated. "Thus, there is an urgent need to improve methods of identifying individuals with high risk for developing the disease, and also to utilize novel digital platforms and technology to personalize treatment and prevention."
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Meanwhile, Experts from Cedars-Sinai Cancer have analyzed patient samples, along with studies conducted in animal models, to identify a novel immune checkpoint pathway to treat hepatocellular carcinoma, the most common form of liver cancer. This big data analysis, coupled with existing immune-boosting therapies, provides a new frontier for treatment strategies.
The findings—centered on the discovery of a novel role for the IL-27 signaling pathway in liver cancer—were published in Cancer Discovery.
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