The comedian declared that the only thing that could prevent victory for the former First Lady would be if she "showed any support for lockdowns and mandates and all this craziness that's going on."
"She's great, she's articulate, she's intelligent, she's the wife of the best President that we have had in our lifetime ... she can win," Rogan exclaimed.
He joked that Obama, 57, should team up with Vice President Kamala Harris as her running mate, assembling a "double dose of diversity."
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Speaking on The Joe Rogan Experience Podcast, he suggested that a Republican "super team" lining up against the pair would be "Trump and [Florida Governor Ron] DeSantis together."
"They have to make a super team. That's the only way they win," Rogan said.
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Speaking in a more serious tone, the podcaster asserted that Obama could clinch the White House as long as she avoided the pro-lockdown, anti-business policies which the Democrat party has embraced.
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"The only thing that would stop her is if she bought into some of these policies that are destroying businesses in America that are making people scared," Rogan said.
"If she somehow or another supported or showed any support for lockdowns and mandates and all this craziness that's going on."
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Obama has not signaled any intention to run thus far, yet many people predict that she could provide stiff opposition against Trump's expected efforts to retake the White House.
President Joe Biden last week confirmed that he indeed intends to run again if he remains in "good health" while Trump mounting a presidential bid would only "increase the prospect."
Rumors are swirling that the DNC will be looking to back another runner, with Vice President Harris the hot favorite to take up the mantle.
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Both potential candidates have had their hopes flattened by poor polling numbers, with a recent Gallup survey finding Biden had a disapproval rating of 51 percent, with Harris close behind bringing in a 54-point negative job rating.
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Bookmakers currently have former First Lady Obama priced as an outside shot at 25/1 - the eighth favorite behind Trump, Biden, Harris, DeSantis, Mike Pence, Nikki Haley and Pete Buttigieg.
There are longer prices to be had on Tucker Carlson (33/1), Dwayne 'The Rock' Johnson (33/1), Oprah Winfrey (33/1) and Meghan Markle (150/1).
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