Speaking with Amanda Knox, the woman who was acquitted in Italy's Supreme Court after being accused of murder as an exchange student, on his podcast, Rogan announced that Trump would "100% try" after being asked if he thinks the 45th president will run in 2024.
"He's probably going to win," Rogan announced following Knox's comparison between former Italian Prime Minister Silvio Berlusconi and Trump.
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"How is Joe Biden going to win? How is it possible he's going to beat anybody?" Rogan asked. "After you've seen him speak, after you've seen the decay and the decline, how is that possible? They've done a terrible job. The Democrats f***ed up royally by making that guy the president."
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Biden is "not very inspiring," Knox stated, though she suggested that Democrats would probably let someone else run, like Vice President Kamala Harris.
"She would lose just as badly," Rogan stated. "She is the most hated vice president according to polls — the least liked, I should say, vice president in 50 years."
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The podcast host told Knox that Harris had been revealed in her 2020 presidential campaign by former Rep. Tulsi Gabbard, a Hawaii Democrat.
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Returning to the idea of a rematch between Biden and Trump, Rogan was adamant in his view of who would emerge as victorious.
"It's crazy. It's crazy that that's the choice. Like you have Donald Trump or a man who's got something seriously wrong, right?" he stated. "He's a guy who's had multiple aneurysms, had actual brain surgery, and is 78 years old and is experiencing some sort of pretty radical cognitive decline."
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Rogan concluded by proposing that Biden might not even be the one running the administration.
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He "is in some way controlled by the other people in the party, whether it is Nancy Pelosi or whoever else," he stated. "He keeps saying things like, 'They tell me not to answer questions,' or, 'They tell me not to.' … Hey motherf***er, you're the president!"
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Meanwhile, Trump suggested in an interview Friday night that only a "bad call from a doctor" would prevent him from seeking another White House bid.
Trump, who has openly flirted with launching another presidential campaign while so far declining to reveal his plans for 2024, was asked by television host David Brody what might prevent him from running again.
"Well, I don't — I guess a bad call from a doctor or something, right?" Trump said on "The Water Cooler" show on Real America's Voice.