This trend, which has been observed since 2021, is raising eyebrows in the medical community, with cancers typically seen in septuagenarians and octogenarians now being diagnosed in individuals in their 40s. This includes bile duct and rare blood cancers, as reported by the Daily Mail.
The COVID-19 pandemic, which forced people into isolation and deterred them from seeking preventative care, is believed to be a significant factor in this disturbing trend. However, doctors are increasingly suspecting that the virus itself, rather than the delay in screening, is the primary culprit behind the surge in advanced, rare cancer cases.
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Dr. Kashyap Patel, a North Carolina-based oncologist, has witnessed this trend firsthand. In 2021, he treated a patient in his 40s with a rare bile duct cancer, a condition usually seen in much older individuals. Furthermore, he has encountered an array of different cancers in his patients, a phenomenon he has not seen in his two decades of medical practice.
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Among his patients were Bob and Bonnie Krall of Fort Mill, South Carolina, who were diagnosed with three types of cancer within a 14-month period, despite having no genetic predisposition. "It’s like a cold. It seems like everyone has it," said Mr. Krall, who was diagnosed with a rare chronic blood and bone marrow cancer, while his wife had an abdominal malignancy weighing eight and a half pounds, according to the Washington Post.
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The link between viruses and cancer is not new. Since the 1960s, it has been known that viruses can accelerate cancer, with a quarter of all cancers worldwide believed to originate from HPV, Epstein-Barr virus, and hepatitis B. However, the potential link between COVID-19 and cancer is a relatively new area of research, given that the pandemic only began four years ago.
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A 2023 report in the journal Biochimie detailed how the Coronavirus can alter genes that usually inhibit tumor formation and cause widespread inflammation throughout the body. This inflammation could potentially lead to the development of cancer cells in various organs, including the lungs, pancreas, and colon.
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Dr. Ashani Weeraratna of the Johns Hopkins Bloomberg School of Public Heath, while not surprised by these findings, emphasized the importance of mitigating infection risk for cancer patients. "Based on the study’s findings, measures adopted by vulnerable patients starting in the early days of the pandemic — wearing masks, avoiding crowded places, getting vaccines — become even more important," she said.
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Dr. Patel is currently researching this connection. His office has recorded over 15 patients with multiple cancers, about 35 with rare cancers, and 15 couples with new cancers since the pandemic began. He suggests that multiple infections and pandemic-related stress, which exacerbates whole-body inflammation, could reactivate cancer cells.
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Even as early as the first wave of the Covid pandemic up to December 31, 2020, doctors began noticing an increase in cancer cases. A 2023 report in the journal Lancet Oncology analyzed 2.4 million adults diagnosed with cancer in 2018, 2019, and 2020. The study found that new cancer cases fell after the start of the pandemic, but began to rise again towards the end of the year.
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The odds of being diagnosed with an advanced stage 4 cancer was more than seven percent higher in 2020 compared to the previous year. Dr. Xuesong Han, a top researcher at the American Cancer Society and lead author of the Lancet Oncology study, suggested that biological mechanisms related to the coronavirus could be a factor. "I don’t have the data to support this opinion. But it’s an important question to follow up on," he said.
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This emerging health crisis underscores the far-reaching and unforeseen consequences of the COVID-19 pandemic. As the medical community grapples with this alarming trend, the importance of preventative measures and continued research into the virus's long-term effects becomes increasingly clear.
