Maher, 66, who frequently attracts criticism of both aisles of the political debate on his long-running show, largely went after the transgender part of that acronym in his editorial.
He began by stressing the polls show the number of Americans identifying as LGBTQ has increased with each passing generation, joking that "if we follow this trajectory, we will all be gay in 2054."
Maher then asked if people are allowed to see those increases and asked: "What's up with that?"
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"It wasn't that long ago that when adults asked children what they wanted to be when they grew up, they meant what profession," Maher said.
He then shifted to suggest that the number of LGBTQ Americans had risen so high, a recent ACLU finding claimed abortion rights bans would impact LGBTQ people more than cisgender women giving birth.
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"Someone needs to say it - not everything's about you. It's okay to ask questions about something very new," Maher said.
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He then addressed puberty blockers, which are given to transgender youth, which Maher called "literally experimenting on children" and suggested that the long-term effects haven't been explored enough, showing studies that said it caused lack of bone density and infertility.
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Maher also cracked about the upcoming Pride parade in New York City not including gay men, but only trans people and lesbians.
"That's where we are now - gay men are not hip enough for a Gay Pride parade. Gay is practically cis, and cis is practically Mormon," he said, showing a photo of Senator Mitt Romney.
Maher then suggested the number of people identifying as LGBTQ is "trendy" because teenagers like to challenge "the squares who brought you up' and wondering why he saw so many transgender children in his home of California but not in Youngstown, Ohio or the rest of the country."
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He said that giving children’s requests for puberty blockers and genital surgery makes them part of a culture war they shouldn’t be a part of.
"Never forget childen are impressionable and very, very stupid," Maher said. "A boy who thinks he's a girl maybe is just gay - or whatever [the television character] "Frasier" was. "And maybe, if life makes you sad, there are other solutions than hand me the d**k saw," he added.
Maher covered it up by saying that while gender is fluid, that "kids are fluid about everything" and want to be different things when they grow up from one day to the next.