"So my advice to everyone out there who's frustrated, sad, angry, pissed off - feel these emotions, go to a kickboxing class, have a margarita, do whatever you need to do this weekend and then wake up on Monday morning, we've got to keep fighting," Psaki said.
She stressed that the "path forward" is to "keep fighting," as the current make-up and rules of the Senate will continue to prevent voting rights bills from being passed.
At the end of the interview, Behar also asked Psaki if she still planned to leave the job sometime this year. "I don't know when I'm leaving. This is an honor and a privilege and I love working for President Obama-Biden," she said, almost blundering and saying her ex-boss's name.
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"I love spending time with him, hearing what's on his mind. Going on the road with him is actually the best thing possible. I wish everybody could have that experience because he gets so much joy out of it," she continued. "No one likes a rope line more than President Biden."
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But Psaki also said that she has "two little kids," a boy who is three, and her six-year-old daughter Vivi, who was often photographed at the White House during the Obama years.
"So I spend a lot of time here, it's a joy," she said, as she had done the interview remotely from the White House. "But I'm also potty-training my 3-year-old, my 6-year-old is in kindergarten and I don't want to miss things in their life either."
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"I also think that this is a job where it will be time for a new face at a certain point in time," she added. "And I don't know when that's going to be."
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It was also one of those weeks that might have made leaving seem like a relief.
"Look, I think this week has been frustrating, devastating, angering - all of those things," Psaki said after the Senate votes failed.
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She pointed out that a year ago, there were more Democrats who were against changing the filibuster rules.
On Wednesday, only two Democrats - moderate Sens. Kyrsten Sinema and Joe Manchin - voted with Republicans to support the current filibuster rules in place, currently requiring 60 votes to reach a verdict.
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Senate Majority Leader Chuck Schumer had proposed a "talking filibuster," where senators would have to hold the floor if they wanted to filibuster a bill and then once time ran out, solely a narrow majority could vote to wrap up debate.
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