"There's only a five-seat majority for the Democrats, the lowest it's been in a hundred years," McCarthy told Fox host Maria Bartiromo.
"That number 25 is a very big number for Democrat retirements. In 2010 when we won the majority, 17 Democrats retired. Already 25 -- I expect that number to be up to over 30 Democrat retirements because they see what the future holds, and they see the numbers."
Democrats have held a slim majority throughout Biden's first year in Congress, dividing the Senate 50-50 and the House 221 to 212. At the end of this year, 25 Democrats are retiring or running for a different office compared to only 12 Republicans doing the same.
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Though, many factors, including President Joe Biden's low poll numbers, skyrocketing inflation, and the over two dozen retiring caucus members, make retaining that edge an uphill battle.
McCarthy added a pitch for voters to help them oust the existing House Speaker, telling Bartiromo: "We need people to join with us to be able to fire Nancy Pelosi."
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In the meantime, the California Republican appeared on Fox News to discuss the minority party's agenda in the 2022 legislative session and provided a brief preview into his sweeping plan to investigate the Biden Administration two years into the President's first term.
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"It really should be a different focus about securing our border, getting small businesses back to work -- make it easier, not harder to open a small business. Crime throughout this country. Let's make our streets, our neighborhoods, our schools safer again. And more importantly, what the Republicans have to offer, a parents' bill of rights. Let's make sure our parents have a say in our kids' education," when asked regarding the 2022 agenda.
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A great battle in the forthcoming weeks, McCarthy announced, would be the fight over federal voting legislation.
He explained Democrats were trying to push through the Senate H.R. 1, or the House-passed For The People Act, to federalize voter protections amid an onslaught of GOP-controlled states imposing limitations on voting in the name of election security.
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"That is where the emphasis needs to be, to be able to not let them break the system, to change the system when it comes to elections and make them unfair in the process," McCarthy announced.
Senate Democrats are looking to resuscitate the Freedom to Vote Act, a compromise bill written out after Moderates voiced concern over whether the For The People Act went too far.