The former presidential candidate told MSNBC's Willie Geist that Democrats is in dire need of candidates who could win in purple states if it was to have a Congress that will "get things done."
Her comments reflect divisions in both parties, as centrists grapple with fringes that offer ideological purity and headline-generating Twitter accounts.
For Democrats, that indicates the so-called Squad of progressives - including the likes of Reps Alexandria Ocasio-Cortez and Ilhan Omar.
"I think that it is a time for some careful thinking about what wins elections, and not just in deep blue districts where a democrat and a liberal Democrat or so-called progressive Democrat is going to win," insisted Clinton.
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Earlier this month, she made her comments in an interview, which was broadcast on Thursday.
In a discussion of the state of the Democratic Party, she declared: "We've got to be very clear-eyed about what it's going to take to hold the House and the Senate in 2022. And to win the electoral college because also Republicans are doing everything they can to create an environment in which winning the Electoral College, even narrowly the way Joe Biden did will be out of reach for Democrats."
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She noted that she understood why politicians would want to argue for their own priorities.
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"But at the end of the day, nothing is going to get done if you don't have a Democratic majority in the House, in the Senate, and our majority comes from people who win in much more difficult districts and our majority in the Senate comes from people who can win in not just blue states and hold those wins ... but can win in more purpleish states," she stressed.
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Her words came soon after the party's defeat in Virginia's gubernatorial election and as the party prepares for a backlash against President Biden in next year's midterms.
She voiced her favor in a vigorous debate about how to move forward.
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"But at the end of the day, it means nothing. If we don't have a Congress that will get things done and we don't have a White House that we can count on to be sane and sober and stable and productive," she went on.
"So this is going to be a very intense period, not just for the Democratic Party, but for the country."
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Her comments put her at odds with the Progressive wing of her own party, which has at times opposed President Biden.
So although his Administration hails a $1 trillion bipartisan infrastructure bill as among its biggest achievements, the squad opposed its progress unless a far wider social spending program accompanied it.
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