Manchin further announced he would not back any step to weaken the ability of Republicans to mount filibusters to block legislation. Some Democrats want to throw aside the filibuster rule, which needs 60 votes in the 100-member chamber to approve most bills.
"I simply do not believe budget reconciliation should replace regular order in the Senate," Manchin announced in an opinion piece in the Washington Post. "Senate Democrats must avoid the temptation to abandon our Republican colleagues on important national issues."
Democrats relied on the budget reconciliation process to bypass a potential Republican filibuster and pass Biden's $1.9 trillion coronavirus relief bill in March with a simple majority in the Senate. They have been weighing doing the same with Biden's suggested infrastructure package.
"The filibuster is a critical tool to protecting that input and our democratic form of government. That is why I have said it before and will say it again to remove any shred of doubt: There is no circumstance in which I will vote to eliminate or weaken the filibuster,” Manchin stated.
"Every time the Senate voted to weaken the filibuster in the past decade, the political dysfunction and gridlock have grown more severe," Manchin addressed, explaining it was time to end "political games" and return to a "new era of bipartisanship."
The centrist Democrat from West Virginia announced last month he could see making filibusters more "painful" to carry out, although he was not in favor of abolishing them.
Biden announced two weeks ago that the procedural maneuver was being mistreated "in a gigantic way" and should be more challenging to carry out. He explained that he favored a return to the "talking filibuster" - a tradition from decades ago that required senators to occupy the floor and make their case against legislation if they rejected it.
Manchin has been willing on some matters to cross party lines, so his support is important to any bill passing in the 50-50 Senate. Democrats dominate the chamber because Vice President Kamala Harris can break a tie.
The Senate parliamentarian ordered on Monday that Democrats could use reconciliation to pass more legislation this year, and Democrats were considering using the process to pass Biden's infrastructure investment package.
Biden wished to spend $2.3 trillion on roads and bridges, retrofitting homes, expanding broadband internet access, caring for the elderly, building up domestic manufacturers and building high-speed rail, a proposal that has run into stiff resistance from Republicans.