The "Squad" leader told reporters in Washington, D.C. Friday that survivors "deserve to be heard."
She said the "process for hearing this allegation falls squarely in the state legislature."
At the same time, New York attorney general Letitia James is reviewing a letter from state Republicans to review the accusations against Cuomo.
Lindsey Boylan, the former deputy secretary for economic development and special adviser to Cuomo, issued an essay on Medium this week charging the three-term governor with kissing her without consent and consistently making inappropriate, sexually charged remarks. She said many other women had shared with her similar occurrences.
Boylan is running for Manhattan district president.
"Let's play strip poker," Boylan said Cuomo remarked on a flight from an event in October 2017.
Boylan, detailing a meeting in December 2016, said Cuomo arranged through a handler to meet her in his Albany office and she agreed hesitantly. She said he gave her a tour of his office, "smirked" and showed off a cigar box he said was given to him by former President Bill Clinton while he worked as the secretary of Housing and Urban Development.
Boylan said she read that to be an innuendo referencing the affair between Clinton and his then-intern Monica Lewinsky in the mid-1990s.
"Governor Andrew Cuomo has created a culture within his administration where sexual harassment and bullying is so pervasive that it is not only condoned but expected. His inappropriate behavior toward women was an affirmation that he liked you, that you must be doing something right. He used intimidation to silence his critics," she writes.
Boylan said in another incident, this time in Cuomo's New York City office, he kissed her on the lips.
"I was in shock, but I kept walking," Boylan wrote.
"The idea that someone might think I held my high-ranking position because of the Governor'scrush' on me was more demeaning than the kiss itself."
Another Democratic New York lawmaker, Sen. Kristen Gillibrand, said she’d not read the accusations against Cuomo.
She added: "Well, obviously these allegations are serious and deeply concerning, and anyone has a right to come forward to be heard and to have allegations be investigated.
"Governor Cuomo also has a right to be heard and he has come forward and has denied these allegations. But ultimately the decision will be up to the state," Gillibrand said.
This is the second time in a week Ocasio-Cortez has called for a probe into the governor. Earlier, she called for an investigation into his handling of nursing homes during the coronavirus pandemic.