On Monday the 56-year-old had toasted Joe Biden's win during his first show since his victory was announced with a glass of champagne for him and his wife, Evie McGee-Colbert.
But by Tuesday Colbert was telling viewers: 'Yesterday, I was pouring champagne to toast the administration, and today I will cut you if you come near me, because there's some crazy s*** going on out there.'
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In response to the 2020 election Trump has sought to discredit the integrity of the election and argued without evidence that the results will be overturned.
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Colbert pointed out that 'peaceful transitions are important', adding: 'You don't see me starting the show every night getting in a knife fight with David Letterman.'
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After McConnell said Trump is '100% within his rights' to question election results Colbert had this to say: 'So the Republican Party is backing the president. Not because they believe his conspiracy theories, but because they're afraid of making him mad because they need his base.'
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Colbert then moved on to Pompeo's speech on Tuesday in which Pompeo told reporters with a grin that the 'transition' to a second Trump term would be 'smooth'.
The host continued: 'No. Wrong.. nothing this administration has done has ever been smooth. He couldn't even manage a smooth transition from stage to ground level.’