According to the U.S. Treasury Department's 2010 sanctions, Zahedi was identified as a pivotal figure in Iran's backing of the Lebanese militant group Hezbollah.
Reportedly, Reuters correspondents present at the scene in the Syrian capital witnessed smoke billowing from the remains of a structure decimated in the airstrike.
When questioned about the incident, an Israeli military spokesperson informed Reuters, "We do not comment on reports in the foreign media."
The U.S. Treasury's 2010 statement highlighted Zahedi's role as a liaison to Hezbollah and Syrian intelligence services, tasked with ensuring the delivery of weapons to Hezbollah.
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Tensions between Hezbollah and the Israeli military have led to frequent border clashes since the commencement of the Israel-Hamas conflict on October 7.
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Earlier in February, Israel confirmed the elimination of a senior Hezbollah commander, Ali Muhammad Aldbas, in a strike carried out in Lebanon. The Israel Defense Forces disclosed that the operation targeted a "Hezbollah military structure" in Nabatieh, resulting in the deaths of Aldbas, his deputy commander Ibrahim Issa, and another militant.